The City of Johns Creek is located in the northeast corner of Fulton County; bounded on the south by the Chattahoochee River, on the east by Gwinnett County and the Chattahoochee, on the north by Forsyth County and on the west by the cities of Alpharetta and Roswell.
- From Rt. 400: Exit 10, East on Old Milton Parkway to Johns Creek
- From I-85 Northbound: Exit at Rt. 120, West on Duluth Highway (Rt. 120) to Johns Creek
- From I-85 Southbound: Exit 111, NE on Lawrenceville-Suwanee Road (Rt. 317N), Left on Satellite Boulevard, Right on McGinnis Ferry Road to Johns Creek
- From 285: Exit 31, North on Rt. 141 to Johns Creek